SMYD3 DRIVES CELL CYCLE AND EPITHELIAL-MESENCHYMAL TRANSITION PATHWAYS THROUGH DUAL GENE TRANSCRIPTIONAL REPRESSION AND ACTIVATION IN HPV-NEGATIVE HEAD AND NECK CANCER

Gift Cards Abstract Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type in the world and is associated with an overall poor prognosis.The protein methyltransferase SET and MYND domain-containing 3 (SMYD3), which trimethylates H3K4, activates gene transcription and enhances several o

Many neurons display bistability--coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence.Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a brief signal High Heat Plastic Food Pan Covers to

Notions of the smart city look to mobilize information technology to increase organizational efficiency, and more recently, to support new forms of community engagement and involvement in addressing municipal issues.As cities turn Hallway Runner to civic enterprise technology platforms, we need to better understand how that class of system might be

BACKGROUND:RA patients being treated with biologics are known to have an increased risk of infections.We recently demonstrated that both CTLA4 Ig and anti-TNF treatment aggravate systemic Staphylococcus aureus (S.aureus) infection in mice, but with distinct clinical manifestations.However, the effects of CTLA4 Ig and anti-TNF treatments on a local

Condition monitoring plays an important role in rotating machinery to ensure reliability of the equipment, and to detect fault conditions at an early stage.Although health monitoring methodologies have been thoroughly developed for rotating machinery, low-speed conditions often pose a challenge due to the low signal-to-noise ratio.To this aim, soph